@article {Wu:2011:1027-3719:125,
title = "Aerodigestive tract, lung and haematological cancers are risk factors for tuberculosis: an 8-year population-based study",
journal = "The International Journal of Tuberculosis and Lung Disease",
parent_itemid = "infobike://iuatld/ijtld",
publishercode ="iuatld",
year = "2011",
volume = "15",
number = "1",
publication date ="2011-01-01T00:00:00",
pages = "125-130",
itemtype = "ARTICLE",
issn = "1027-3719",
eissn = "1815-7920",
url = "https://www.ingentaconnect.com/content/iuatld/ijtld/2011/00000015/00000001/art00022",
keyword = "tuberculosis, aerodigestive tract, cancer, lung, haematological",
author = "Wu, C-Y. and Hu, H-Y. and Pu, C-Y. and Huang, N. and Shen, H-C. and Li, C-P. and Chou, Y-J.",
abstract = "SETTING: The deterioration of immunity in cancer patients may be associated with a higher incidence of tuberculosis (TB).OBJECTIVE: Despite several previous studies on cancer and TB, no population-based investigation has been published. We performed a nationwide population-based study to investigate the incidence of active TB among cancer patients, and the cancer-type specific risk factors related to TB.DESIGNS: This nationwide population-based retrospective cohort study was based on data obtained from the Taiwan National Health Insurance Database. A total of 16487 cancer patients and 65948 controls matched for age and sex were recruited.RESULTS: The incidence of TB per 100000 person-years was 339 in the cancer patients and 202 in the controls, which gives a crude incidence rate ratio of 1.68 (95%CI 1.421.98). The hazard ratio (HR) was 1.67 (95%CI 1.421.96) after adjusting for age, sex and comorbidity. Cox regression showed that cancers of the aerodigestive tract, including oral, nasopharyngeal and oesophageal and lung cancer (HR 3.09, 95%CI 2.423.94) and haematological cancers, including non-Hodgkin's lymphoma and leukaemia (HR 3.22, 95%CI 1.985.22), were significant risk factors for TB.CONCLUSION: Cancer patients have a higher incidence of TB than controls. Patients with aerodigestive tract, lung and haematological cancers are especially vulnerable to TB.",
}