Aerodigestive tract, lung and haematological cancers are risk factors for tuberculosis: an 8-year population-based study
Abstract:SETTING: The deterioration of immunity in cancer patients may be associated with a higher incidence of tuberculosis (TB).
OBJECTIVE: Despite several previous studies on cancer and TB, no population-based investigation has been published. We performed a nationwide population-based study to investigate the incidence of active TB among cancer patients, and the cancer-type specific risk factors related to TB.
DESIGNS: This nationwide population-based retrospective cohort study was based on data obtained from the Taiwan National Health Insurance Database. A total of 16 487 cancer patients and 65 948 controls matched for age and sex were recruited.
RESULTS: The incidence of TB per 100 000 person-years was 339 in the cancer patients and 202 in the controls, which gives a crude incidence rate ratio of 1.68 (95%CI 1.42–1.98). The hazard ratio (HR) was 1.67 (95%CI 1.42–1.96) after adjusting for age, sex and comorbidity. Cox regression showed that cancers of the aerodigestive tract, including oral, nasopharyngeal and oesophageal and lung cancer (HR 3.09, 95%CI 2.42–3.94) and haematological cancers, including non-Hodgkin's lymphoma and leukaemia (HR 3.22, 95%CI 1.98–5.22), were significant risk factors for TB.
CONCLUSION: Cancer patients have a higher incidence of TB than controls. Patients with aerodigestive tract, lung and haematological cancers are especially vulnerable to TB.
Document Type: Regular Paper
Affiliations: 1: Institute of Public Health, National Yang-Ming University, Taipei, Taiwan; Division of Dermatology, Taipei County Hospital, Taipei, Taiwan 2: Department of Senior Citizen Service Management, Ching-Kuo Institute of Management and Health, Keelung, Taiwan 3: Institute of Public Health, National Yang-Ming University, Taipei, Taiwan 4: Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan 5: Division of Surgery, Taipei County Hospital, Taipei, Taiwan 6: Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; National Yang-Ming University School of Medicine, Taipei, Taiwan
Publication date: January 1, 2011
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