MODS accreditation process for regional reference laboratories in Peru: validation by GenoType® MTBDRplus
OBJECTIVE: To evaluate the validity of MODS-based accreditation and the concordance of MODS drug susceptibility testing (DST) with molecular testing.
DESIGN: Head-to-head comparison of MODS DST results from implementing Peruvian regional reference laboratories and the accrediting expert MODS laboratory (UPCH) with GenoType® MTBDRplus DST.
RESULTS: The concordance of phenotypic MODS rifampicin (RMP) DST with GenoType MTBDRplus was respectively 97.4%, 97.9% and 97.1% for the two implementing regional laboratories and UPCH, and respectively 94.7%, 95.7% and 94.6% for isoniazid (INH) DST.
CONCLUSION: High and consistent levels of MODS/MTBDRplus concordance for INH and RMP DST confirm the validity of the use of rapid methods as reference standards for accreditation.
Document Type: Regular Paper
Affiliations: 1: Laboratorio de Investigación de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru 2: Health Protection Agency, National Mycobacterium Reference Laboratory, London, UK 3: Dirección Regional de Salud, Callao, Lima, Peru 4: Dirección de Salud Lima Sur, Lima, Peru 5: Laboratorio de Referencia Nacional de Micobacterias, Instituto Nacional de Salud, Lima, Peru
Publication date: 2010-11-01
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