The MIT D-lab electricity-free PortaTherm™ incubator for remote testing with the QuantiFERON®-TB Gold In-Tube assay
OBJECTIVE: To determine whether the PortaTherm can be used for the reliable incubation of QFT-GIT samples, thus enabling QFT-GIT use in settings distant from laboratory facilities.
METHODS: In a prospective comparative study in Peru, blood samples were collected from 50 participants and processed in three parallel QFT-GIT tests per participant; two were incubated in a conventional incubator; the third was incubated in the PortaTherm.
RESULTS: All 150 QFT-GIT tests gave definitive results, and for 46 of the 50 participants all three tests were concordant, eight of which were positive. Four participants had one discordant result: two due to discordance of a conventional incubator QFT-GIT result, and two due to discordant PortaTherm QFT-GIT results.
CONCLUSION: The QFT-GIT inter-incubator variability between the PortaTherm and conventional incubator was no greater than the intra-incubator variability for the conventional incubator, indicating that the PortaTherm is a suitable tool for incubating QFT-GIT whole blood samples in remote settings where access to a laboratory or electricity is limited.
Document Type: Regular Paper
Affiliations: 1: Universidad Peruana Cayetano Heredia, San Martin de Porres, Lima, Peru 2: D-Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA 3: Universidad Peruana Cayetano Heredia, San Martin de Porres, Lima, Peru; and Department of Emergency Medicine, Yale–New Haven Hospital, New Haven, Connecticut, USA
Publication date: 2010-11-01
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