Latent tuberculosis infection among close contacts of multidrug-resistant tuberculosis patients in central Taiwan
OBJECTIVE: To evaluate the transmission status of MDR-TB patients in Taiwan by examining their close contacts and to compare the efficiency of TST and QFT-GIT.
DESIGN: Chest radiographs, TST and QFT-GIT were performed in household contacts of confirmed MDR-TB patients to determine their infection status.
RESULTS: A total of 78 close contacts of confirmed MDR-TB patients were included in the study. The majority of the MDR-TB patients were parents of the close contacts and lived in the same building; 46% of the subjects were TST-positive and 19% were QFT-GIT-positive, indicating LTBI that was likely to develop into active MDR-TB. There was a lack of consistency between TST and QFT-GIT results in subjects with previous bacille Calmette-Guérin vaccination.
CONCLUSION: Household contacts of MDR-TB patients are likely to develop LTBI; thus, follow-up and monitoring are mandatory to provide treatment and reduce the occurrence of active infection.
Document Type: Regular Paper
Affiliations: 1: Department of Tuberculosis, Changhua Hospital, Taiwan Department of Health, Changhua City, Taiwan 2: Pulmonary and Critical Care Medicine Section, Taichung Veterans General Hospital, Taichung, Taiwan 3: Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, and Tzu Chi University, Hualien, Taiwan 4: Department of Tuberculosis, Taichung Hospital, Taiwan Department of Health, Taichung, Taiwan
Publication date: 2010-11-01
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