Skip to main content

Free Content Anti-tuberculosis drug resistance in new and previously treated pulmonary tuberculosis cases in Burkina Faso

Download Article:
 Download
(PDF 255.6 kb)
 

Abstract:

SETTING: National Tuberculosis (TB) Control Centre in Ouagadougou, Burkina Faso.

OBJECTIVE: To evaluate Mycobacterium tuberculosis drug resistance among newly diagnosed and previously treated cases.

METHODS: A total of 416 M. tuberculosis complex strains were isolated from 323 new and 93 previously treated patients under DOTS. Susceptibility to four anti-tuberculosis drugs (isoniazid [INH], rifampicin [RMP], streptomycin [SM] and ethambutol [EMB]) was determined using the proportion method. Human immunodeficiency virus (HIV) status was determined in 316 patients, 249 new and 67 previously treated cases, with informed consent.

RESULTS: Among new cases, 12.4% of strains were resistant to any drug, and 3.4% were multidrug-resistant (MDR). Resistance rates were very high in previously treated patients: INH (66.7%), RMP (51.6%), SM (44.1%), EMB (50.5%) and MDR (INH+RMP; 50.5%). Of 316 patients tested, 28.7% were HIV-positive. There was no statistically significant association between HIV status and MDR-TB in new (P = 0.95) and previously treated patients (P = 0.5).

CONCLUSION: Drug resistance is high in Burkina Faso. Early detection of infectious patients and completion of treatment are essential.

Keywords: Burkina Faso; Mycobacterium tuberculosis; resistance; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Centre National de Lutte Antituberculeuse, Ouagadougou, Burkina Faso; and Unité de Formation et de Recherches Sciences de la Vie et de la Terre, Université de Ouagadougou, Ouagadougou, Burkina Faso 2: Centre National de Lutte Antituberculeuse, Ouagadougou, Burkina Faso 3: Unité de Formation et de Recherches Sciences de la Vie et de la Terre, Université de Ouagadougou, Ouagadougou, Burkina Faso

Publication date: November 1, 2010

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
iuatld/ijtld/2010/00000014/00000011/art00011
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more