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Home / The International Journal of Tuberculosis and Lung Disease, Volume 14, Number 11

Diagnostic value of adenosine deaminase in cerebrospinal fluid for tuberculous meningitis: a meta-analysis [Review article]

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Authors: Xu, H-B. 1 ; Jiang, R-H. 2 ; Li, L. 1 ; Sha, W. 2 ; Xiao, H-P. 2 ; 

Source: The International Journal of Tuberculosis and Lung Disease, Volume 14, Number 11, November 2010, pp. 1382-1387(6)

Publisher: International Union Against Tuberculosis and Lung Disease

OBJECTIVE: To determine the accuracy of adenosine deaminase (ADA) measurements in the diagnosis of tuberculous meningitis (TBM).

DESIGN: After a systematic review of English language studies, the sensitivity, specificity and accuracy of ADA concentrations in the diagnosis of cerebrospinal fluid (CSF) were evaluated using random effects models. Summary receiver operating characteristic curves were used to summarise overall test performance.

RESULTS: Ten studies met our inclusion criteria. The sensitivity of ADA in the diagnosis of TBM was 0.79 (95%CI 0.75–0.83), specificity 0.91 (95%CI 0.89–0.93), positive likelihood ratio 6.85 (95%CI 4.11–11.41), negative likelihood ratio 0.29 (95%CI 0.19–0.44) and diagnostic odds ratio 26.93 (95%CI 12.73–56.97).

CONCLUSION: Our data suggest that ADA in the CSF can be a sensitive and specific target and a critical criteria for the diagnosis of TBM.

Keywords: adenosine deaminase; cerebrospinal fluid; tuberculosis

Document Type: Review Article

Affiliations: 1: Department of Clinical Pharmacy, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China 2: Department of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

Publication date: 01 November 2010

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