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Free Content South Carolina tuberculosis genotype cluster investigation: a tale of substance abuse and recurrent disease [Notes from the field]

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The South Carolina Tuberculosis (TB) Control Division ranked all the TB genotype clusters (two or more cases with matching genotypes) in the state based on the number of cases. The largest cluster, PCR00002, was investigated to determine if the cluster represented recent Mycobacterium tuberculosis transmission, and if so, to identify associated risk factors. The PCR0002 cluster, which included pediatric cases, clearly represented recent M. tuberculosis transmission. The two primary factors contributing to cluster growth were substance abuse and recurrent TB disease. Elimination of ongoing M. tuberculosis transmission in this population will require concurrent treatment for TB disease and substance abuse.

Keywords: contact tracing; epidemiology; genotype; substance abuse; tuberculosis

Document Type: Short Communication

Affiliations: 1: Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA 2: Tuberculosis Control Division, South Carolina Department of Health and Environmental Control, Columbia, South Carolina, USA 3: Department of Internal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA 4: York County Health Department, Rock Hill, South Carolina, USA

Publication date: October 1, 2010

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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