Chronic mucus hypersecretion: prevalence and risk factors inyounger individuals
OBJECTIVE: To determine prevalence, incidence and risk factors for CMH in a young general population.
DESIGN: A cohort of Danish twins (aged 12–41 years) was prospectively examined using questionnaires in 1994 (n = 29 180) and in 2002 (n = 21 130). Prevalence and incidence of CMH were determined, and risk factors for the condition were assessed using logistic regression.
RESULTS: Lifetime prevalence of CMH was 8.6% in females and 6.9% in males in 1994, and the cumulative incidence among females and males was respectively 10.7% and 8.7% during the study period. Smoking and asthma were risk factors for CMH, with a dose-response effect of tobacco consumption, and smoking habits also predicting incidence of CMH.
CONCLUSION: Among the young, CMH is a condition related to asthma and smoking, with a dose-response relationship with tobacco consumption and a relation between smoking habits and incidence. Female susceptibility to development of CMH was observed, as well as signs of greater susceptibility related to young age.
Document Type: Regular Paper
Affiliations: 1: Respiratory and Allergy Research Unit, Department of Respiratory Medicine L, Copenhagen University Hospital, Bispebjerg, Denmark 2: Department of Pulmonary and Infectious Diseases, Hillerød Hospital, Hillerød, Denmark 3: Department of Occupational and Environmental Medicine, Hospital of Southern Jutland, Haderslev, Denmark 4: Institute of Regional Health Services Research & The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Publication date: 01 August 2010
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