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Free Content Chronic mucus hypersecretion: prevalence and risk factors inyounger individuals

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Abstract:

SETTING: Chronic mucus hypersecretion (CMH) is a common condition in patients with chronic respiratory diseases. Little is known about the incidence, prevalence and determinants of CMH in younger individuals.

OBJECTIVE: To determine prevalence, incidence and risk factors for CMH in a young general population.

DESIGN: A cohort of Danish twins (aged 12–41 years) was prospectively examined using questionnaires in 1994 (n = 29 180) and in 2002 (n = 21 130). Prevalence and incidence of CMH were determined, and risk factors for the condition were assessed using logistic regression.

RESULTS: Lifetime prevalence of CMH was 8.6% in females and 6.9% in males in 1994, and the cumulative incidence among females and males was respectively 10.7% and 8.7% during the study period. Smoking and asthma were risk factors for CMH, with a dose-response effect of tobacco consumption, and smoking habits also predicting incidence of CMH.

CONCLUSION: Among the young, CMH is a condition related to asthma and smoking, with a dose-response relationship with tobacco consumption and a relation between smoking habits and incidence. Female susceptibility to development of CMH was observed, as well as signs of greater susceptibility related to young age.

Keywords: COPD; asthma; chronic mucus hypersecretion; epidemiology; smoking

Document Type: Regular Paper

Affiliations: 1: Respiratory and Allergy Research Unit, Department of Respiratory Medicine L, Copenhagen University Hospital, Bispebjerg, Denmark 2: Department of Pulmonary and Infectious Diseases, Hillerød Hospital, Hillerød, Denmark 3: Department of Occupational and Environmental Medicine, Hospital of Southern Jutland, Haderslev, Denmark 4: Institute of Regional Health Services Research & The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark

Publication date: August 1, 2010

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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