Human immunodeficiency virus increases the risk of tuberculosis due to recent re-infection in individuals with latent infection
METHODS: Individuals experiencing a first TB episode between 1996 and 2008 in Karonga District, Northern Malawi, were included if information on M. tuberculosis infection status (from tuberculin tests) before 1990 and a DNA fingerprint from the TB episode were available. We explored differences in proportion clustered by prior M. tuberculosis infection status and HIV status, adjusting for age, sex, bacille Calmette-Guérin scar status and time since tuberculin testing.
RESULTS: Of 79 HIV-negative TB cases, those with previous M. tuberculosis infection were much less likely to be clustered than cases without prior infection (29% vs. 77%, adjusted OR = 0.15, 95%CI 0.04–0.59). Among 119 HIV-positive TB cases, clustering was similar in both groups (88% vs. 84%, adjusted OR = 1.85, 95%CI 0.41–8.29).
DISCUSSION: HIV infection appears to increase the risk of TB following recent re-infection in patients with latent M. tuberculosis infection. Our results add to the mounting evidence that HIV-associated TB mainly follows recent M. tuberculosis infection.
Document Type: Regular Paper
Affiliations: 1: Infectious Disease Epidemiology Unit, London School of Hygiene & Tropical Medicine, London, UK; Karonga Prevention Study, Chilumba, Malawi 2: Infectious Disease Epidemiology Unit, London School of Hygiene & Tropical Medicine, London, UK; and Karonga Prevention Study, Chilumba, Malawi 3: Infectious Disease Epidemiology Unit, London School of Hygiene & Tropical Medicine, London, UK 4: Karonga Prevention Study, Chilumba, Malawi
Publication date: 2010-07-01
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