Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic [Short communication]
Abstract:Multidrug-resistant (MDR) strains were identified in 40% of 54 strains from patients presenting with tuberculosis (TB) treatment failure or relapse in Bangui, Central African Republic. Results obtained with the MTBDRplus line-probe assay or rpoB sequencing were 86% concordant with rifampicin (RMP) resistant phenotypes, while the amplification refractory mutation system test was 71% concordant. No mutation was found in RMP-susceptible strains. MTBDR>e1>plus and sequencing were concordant with the detection of the S315T mutation in katG in 95% of MDR strains. Sequencing of pncA suggested pyrazinamide resistance in 50% of MDR strains. Knowledge of these resistances should help to implement treatment in low-income countries.
Document Type: Short Communication
Affiliations: 1: Laboratoire des Mycobactéries, Institut Pasteur de Bangui, Bangui, Central African Republic; Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France 2: Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France 3: Laboratoire des Mycobactéries, Institut Pasteur de Bangui, Bangui, Central African Republic
Publication date: June 1, 2010
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