Free Content First national survey of Mycobacterium tuberculosis drug resistance, Madagascar, 2005–2006

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Abstract:

SETTING: A national survey of Mycobacterium tuberculosis resistance was conducted for the first time in Madagascar between October 2005 and July 2007.

OBJECTIVE: To determine resistance rates among new and previously treated cases of pulmonary tuberculosis.

METHODS: In a cluster sampling representative of the general population of the country, 1275 smear-positive tuberculosis patients recruited at 34 sites, 926 new patients and 87 previously treated patients underwent drug susceptibility testing against rifampicin (RMP), isoniazid (INH), streptomycin and ethambutol on Löwenstein-Jensen medium using the indirect proportion method.

RESULTS: Resistance among new cases was 6.5% (95%CI 4.9–8) and among previously treated cases it was 11.5% (95%CI 4.8–18.2). Monoresistance among new cases was 5.8% (95%CI 4.2–7.3), mainly to INH (3.7%). Multiresistance to INH and RMP was 0.2% (95%CI 0–0.5) among new cases and 3.4% (95%CI 0–7.2) among previously treated cases. No significant difference was noted with regard to sex or age.

CONCLUSION: The rates of resistance among new and previously treated cases remain relatively low in Madagascar.

Keywords: Madagascar; national survey; resistance; tuberculosis

Document Type: Regular Paper

Affiliations: 1: National Tuberculosis Programme Madagascar, Department of Tuberculosis and Leprosy Control, Ministry of Health and Family Planning, Antananarivo, Madagascar 2: Department of Epidemiology, Pasteur Institute Madagascar, Antananarivo, Madagascar 3: Department of Mycobacteriology, Pasteur Institute Madagascar, Antananarivo, Madagascar 4: Department of Emergency and Disease Control, Ministry of Health and Family Planning, Antananarivo, Madagascar

Publication date: June 1, 2010

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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