First national survey of Mycobacterium tuberculosis drug resistance, Madagascar, 2005–2006
Abstract:SETTING: A national survey of Mycobacterium tuberculosis resistance was conducted for the first time in Madagascar between October 2005 and July 2007.
OBJECTIVE: To determine resistance rates among new and previously treated cases of pulmonary tuberculosis.
METHODS: In a cluster sampling representative of the general population of the country, 1275 smear-positive tuberculosis patients recruited at 34 sites, 926 new patients and 87 previously treated patients underwent drug susceptibility testing against rifampicin (RMP), isoniazid (INH), streptomycin and ethambutol on Löwenstein-Jensen medium using the indirect proportion method.
RESULTS: Resistance among new cases was 6.5% (95%CI 4.9–8) and among previously treated cases it was 11.5% (95%CI 4.8–18.2). Monoresistance among new cases was 5.8% (95%CI 4.2–7.3), mainly to INH (3.7%). Multiresistance to INH and RMP was 0.2% (95%CI 0–0.5) among new cases and 3.4% (95%CI 0–7.2) among previously treated cases. No significant difference was noted with regard to sex or age.
CONCLUSION: The rates of resistance among new and previously treated cases remain relatively low in Madagascar.
Document Type: Regular Paper
Affiliations: 1: National Tuberculosis Programme Madagascar, Department of Tuberculosis and Leprosy Control, Ministry of Health and Family Planning, Antananarivo, Madagascar 2: Department of Epidemiology, Pasteur Institute Madagascar, Antananarivo, Madagascar 3: Department of Mycobacteriology, Pasteur Institute Madagascar, Antananarivo, Madagascar 4: Department of Emergency and Disease Control, Ministry of Health and Family Planning, Antananarivo, Madagascar
Publication date: 2010-06-01
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