Skip to main content

Free Content MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan

Download Article:
(PDF 348.0498046875 kb)
SETTING: Several matrix metalloproteinase (MMP) polymorphisms favouring the development of lung fibrosis after pulmonary tuberculosis (TB) have been described.

OBJECTIVE: To investigate the association of MMP-1, MMP-9 and MMP-12 polymorphisms with the development of fibrosis in pulmonary TB.

DESIGN: We studied 49 normal subjects and 98 TB patients. We analysed the association between MMP polymorphisms and clinical indices of lung fibrosis by serial chest radiography for 1 year after completion of treatment.

RESULTS: The frequency of the MMP-1(-1607G) polymorphism was significantly higher in TB patients with moderate to advanced pulmonary fibrosis than in those with minimal to mild fibrosis. Having at least one -1607G MMP-1 polymorphism increased the risk of moderate and advanced fibrosis respectively by 5.04 (95%CI 1.25–20.30) and 9.87 (95%CI 2.39–40.88) fold. There was no association of MMP-9(-1562T) and MMP-12(Asn357Ser) polymorphisms with lung fibrosis. The production of MMP-1 from monocytes stimulated by interleukin-1β was increased in subjects with the 1G allele genotype compared to the 2G/2G genotype.

CONCLUSIONS: Patients with MMP-1(-1607G) polymorphism are more vulnerable to more extensive lung fibrosis 1 year after anti-tuberculosis treatment. This may be related to increased MMP-1 activity, leading to enhanced destruction of the matrix with subsequent fibrosis.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: genetic polymorphisms; lung fibrosis; matrix metalloproteinase-1; matrix metalloproteinase-12; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan; and Department of Chinese Medicine, Chang Gung University, Taoyuan, Taiwan 2: Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan 3: Department of Public Health, Chang Gung University, Taoyuan, Taiwan 4: National Heart and Lung Institute, Imperial College, London, UK 5: Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan; and Department of Medicine, Chang Gung University, Taoyuan, Taiwan

Publication date: 2010-05-01

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more