Interferon-gamma release assay clarifies the effect of bacille Calmette-Guérin vaccination in Greek army recruits
METHOD: We conducted a cross-sectional comparison study of 1750 young army recruits. TST was performed on all participants, while QFT-GIT was performed in all subjects with TST > 0 mm and in 18 TST-negative controls (TST = 0 mm).
RESULTS: Among the study subjects, 5.4% (96/1750) had TST indurations of ≥10 mm, and 3.4% (59/1750) had indurations of ≥15 mm. Among subjects with a positive TST, 11.4% (11/96) tested positive on QFT-GIT. All those with QFT-GIT positivity had TST indurations of ≥15 mm, and none of those with TST indurations of 10–14 mm were positive by QFT-GIT. The overall agreement between TST and QFT-GIT was poor (κ = 0.02).
CONCLUSION: We found a significant discordance between TST and QFT-GIT in BCG-vaccinated Greek army recruits consistent with previous studies showing that BCG received after infancy produces false-positive TST reactions. Our findings underline the need for a two-step approach in diagnosing latent TB infection in all BCG-vaccinated individuals: initial TST screening, followed by an IGRA to confirm TST positivity.
Document Type: Regular Paper
Affiliations: 1: Department of Pneumonology, University Hospital of Ioannina, Ioannina, Greece 2: Department of Microbiology, University Hospital of Ioannina, Ioannina, Greece 3: Department of Family Medicine, University Hospital of Ioannina, Ioannina, Greece
Publication date: 01 May 2010
The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website
- Editorial Board
- Information for Authors
- Subscribe to this Title
- International Journal of Tuberculosis and Lung Disease
- Public Health Action
- Ingenta Connect is not responsible for the content or availability of external websites