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Free Content Pharmacokinetics of isoniazid in moderately malnourished children with tuberculosis [Short communication]

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Abstract:

Severe malnutrition is known to affect the pharmacokinetics of isoniazid (INH) in children. However, the effect of moderate malnutrition, which may be more prevalent, is not known. INH was administered to 20 children with tuberculosis at a single dose of 5 mg/kg, and serial blood samples were collected. The serum INH concentrations were higher in the undernourished group but the pharmacokinetic parameters were comparable with those in the normal nutrition group. Weight gain was significantly more in the undernourished group after 1 month of treatment. The study suggests that INH pharmacokinetics may not be significantly altered in children with moderate malnutrition.

Keywords: children; isoniazid; malnutrition; pharmacokinetics; tuberculosis

Document Type: Short Communication

Affiliations: 1: Department of Pharmacology, Maulana Azad Medical College, New Delhi, India 2: Institute of Clinical Research India, New Delhi, India 3: Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India 4: Department of Pediatrics, Maulana Azad Medical College, New Delhi, India 5: Department of Biochemistry, Maulana Azad Medical College, New Delhi, India

Publication date: 2010-03-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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