Pharmacokinetics of isoniazid in moderately malnourished children with tuberculosis [Short communication]
Abstract:Severe malnutrition is known to affect the pharmacokinetics of isoniazid (INH) in children. However, the effect of moderate malnutrition, which may be more prevalent, is not known. INH was administered to 20 children with tuberculosis at a single dose of 5 mg/kg, and serial blood samples were collected. The serum INH concentrations were higher in the undernourished group but the pharmacokinetic parameters were comparable with those in the normal nutrition group. Weight gain was significantly more in the undernourished group after 1 month of treatment. The study suggests that INH pharmacokinetics may not be significantly altered in children with moderate malnutrition.
Document Type: Short Communication
Affiliations: 1: Department of Pharmacology, Maulana Azad Medical College, New Delhi, India 2: Institute of Clinical Research India, New Delhi, India 3: Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India 4: Department of Pediatrics, Maulana Azad Medical College, New Delhi, India 5: Department of Biochemistry, Maulana Azad Medical College, New Delhi, India
Publication date: 2010-03-01
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