The impact of insulin sensitisers on lung function in patients with chronic obstructive pulmonary disease and diabetes
Abstract:SETTING: It has been reported that diabetes mellitus (DM) is associated with poor pulmonary function, which could be explained by insulin resistance.
OBJECTIVE: To evaluate whether insulin sensitisers (ISs) have beneficial effects on lung function in patients with chronic obstructive pulmonary disease (COPD) and DM.
DESIGN: This retrospective study included patients with both COPD and DM who attended Seoul National University Hospital for treatment between 1 January 2000 and 31 August 2007. They were treated with inhalers for COPD and oral hypoglycaemia agents, including ISs or insulin, for DM. The primary outcome was a change in lung function in spirometric examinations.
RESULTS: Among 61 patients enrolled, 32 were in the no IS group, while 29 were in the IS group. On multivariable regression analysis, the IS group showed a significantly greater change in forced vital capacity (FVC) than the no IS group (adjusted β-coefficient 131.9, 95%CI 8.5–255.4, P = 0.04).
CONCLUSIONS: Treatment with an IS was independently associated with improvements in FVC in patients with both COPD and DM, compared with treatment without IS.
Document Type: Regular Paper
Affiliations: 1: Department of Respiratory Medicine, Konkuk University Hospital, Seoul, Republic of Korea 2: Division of Pulmonary and Critical Care Medicine and Lung Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea 3: Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea 4: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, Republic of Korea
Publication date: March 1, 2010
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