Authors: Kim, H.J.¹; Lee, J.Y.²; Jung, H.S.³; Kim, D-K.⁴; Lee, S-M.²; Yim, J-J.²; Yang, S-C.²; Yoo, C-G.²; Chung, H.S.⁴; Kim, Y.W.²; Han, S.K.²; Shim, Y-S.²; Lee, C-H.⁴

Source: The International Journal of Tuberculosis and Lung Disease, Volume 14, Number 3, March 2010 , pp. 362-367(6)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

SETTING: It has been reported that diabetes mellitus (DM) is associated with poor pulmonary function, which could be explained by insulin resistance.

OBJECTIVE: To evaluate whether insulin sensitisers (ISs) have beneficial effects on lung function in patients with chronic obstructive pulmonary disease (COPD) and DM.

DESIGN: This retrospective study included patients with both COPD and DM who attended Seoul National University Hospital for treatment between 1 January 2000 and 31 August 2007. They were treated with inhalers for COPD and oral hypoglycaemia agents, including ISs or insulin, for DM. The primary outcome was a change in lung function in spirometric examinations.

RESULTS: Among 61 patients enrolled, 32 were in the no IS group, while 29 were in the IS group. On multivariable regression analysis, the IS group showed a significantly greater change in forced vital capacity (FVC) than the no IS group (adjusted β-coefficient 131.9, 95%CI 8.5-255.4, P = 0.04).

CONCLUSIONS: Treatment with an IS was independently associated with improvements in FVC in patients with both COPD and DM, compared with treatment without IS.

Keywords: insulin sensitiser; chronic obstructive pulmonary disease; diabetes; lung function; insulin resistance

Document Type: Regular paper

Affiliations: 1: Department of Respiratory Medicine, Konkuk University Hospital, Seoul, Republic of Korea 2: Division of Pulmonary and Critical Care Medicine and Lung Institute, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea 3: Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea 4: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, Republic of Korea

Publication date: 2010-03-01

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• The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

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