Authors: Punga, V.V.¹; Jakubowiak, W.M.²; Danilova, I.D.³; Somova, T.R.⁴; Volchenkov, G.V.⁴; Kazionnyy, B.Y.⁵; Nemtsova, E.S.⁵; Kiryanova, E.V.⁵; Kourbatova, E.V.⁶

Source: The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 10, October 2009 , pp. 1309-1312(4)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

SETTING: Joint World Health Organization (WHO) projects in Vladimir and Orel regions, Russia.

OBJECTIVE: To study the prevalence of extensively drug-resistant (XDR) tuberculosis (TB).

METHODS: Drug susceptibility testing of second-line drugs (ofloxacin, kanamycin, capreomycin, ethionamide, cycloserine and para-aminosalicylic acid) was performed on isolates from multidrug-resistant TB cases from 1 January to 31 December 2006.

RESULTS: In Orel, 16 (21.3%) of 75 tested isolates were XDR-TB; in Vladimir, 9 (4.9%) of 182 isolates were XDR-TB. Bilateral lung involvement was significantly associated with XDR-TB (prevalence ratio = 2.61, 95%CI 1.01-6.72).

CONCLUSION: XDR-TB has emerged in Russia. It is crucial to prevent, diagnose and treat TB and MDR-TB more effectively.

Keywords: tuberculosis; extensively drug-resistant; second-line drugs; drug susceptibility testing

Document Type: Short communication

Affiliations: 1: Central TB Research Institute of Russian Academy of Medical Sciences, Moscow, Russian Federation 2: World Health Organization, TB Strategy and Operations, TB-HIV and Drug Resistance, Geneva, Switzerland 3: Office of the Special Representative of the WHO Director-General in Russia, TB Control Programme, Moscow, Russian Federation 4: Vladimir Oblast Tuberculosis Dispensary, Vladimir, Russian Federation 5: Orel Oblast Tuberculosis Dispensary, Orel, Russian Federation 6: Samara State Medical University, Division of TB and Lung Diseases, Samara, Russian Federation

Publication date: 2009-10-01

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• The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

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