Liquid culture for Mycobacterium tuberculosis: proceed, but with caution [Unresolved issues]
Abstract:Attempts to improve the diagnosis of tuberculosis (TB) in high-burden countries has resulted in significant funding and initiatives to change the method of diagnosis of TB from light microscopy supplemented with X-ray to a sophisticated diagnostic algorithm based on the latest technological innovations. Such activities are overdue and should be welcomed, but the lack of skills and support available to interpret and use the results represents a danger. The introduction of new diagnostic methods, particularly liquid culture, should be carefully structured according to the local situation, failing which frustration and the disruption of previously underdeveloped but adequately functioning laboratories may result.
Document Type: Editorial
Affiliations: 1: Royal Tropical Institute, KIT Biomedical Research, Amsterdam, The Netherlands 2: Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands; and KNCV Tuberculosis Foundation, The Hague,The Netherlands 3: KNCV Tuberculosis Foundation, The Hague, The Netherlands 4: Mycobacterium Reference Laboratory, Microbiology & Infectious Diseases, South Australia Pathology, Rundle Mall, South Australia, Australia 5: Forschungszentrum Borstel, National Reference Center for Mycobacteria, Borstel, Germany 6: Mycobacteria Reference Laboratory, RIVM, Bilthoven, The Netherlands
Publication date: 2009-09-01
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