Mortality benefit of isoniazid preventive therapy in HIV-positive persons: a simulation study [Short communication]

Authors: Bachhuber, M.A.; Gross, R.

Source: The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 8, August 2009 , pp. 1038-1040(3)

Publisher: International Union Against Tuberculosis and Lung Disease

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Abstract:

A meta-analysis of isoniazid preventive therapy (IPT) in human immunodeficiency virus-positive individuals failed to show a mortality benefit even though tuberculosis is a leading cause of death in this group. Results for purified protein derivative (PPD) positive patients were heterogeneous, however, and two of the included trials had many PPD-unknowns. When all PPD-unknowns were allocated to either PPD-positive or PPD-negative, the individual trial results were not robust, and simulated meta-analyses showed an overall reduction in all-cause mortality for PPD-positive individuals on IPT (relative risk 0.76; 95% credibility interval 0.6-0.95).

Keywords: isoniazid; HIV; tuberculosis; mortality

Document Type: Short communication

Affiliations: 1: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

Publication date: 2009-08-01

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The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
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