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Free Content Factors associated with positive tuberculin skin test results among HIV-infected persons in Orel Oblast, Russia

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BACKGROUND: The treatment of persons living with human immunodeficiency virus/acquired immune-deficiency syndrome (PLWHAs) for latent tuberculosis infection (LTBI) reduces tuberculosis (TB) morbidity. Despite a high TB burden and an expanding human immunodeficiency virus epidemic, Russia had limited data on the utility of the tuberculin skin test (TST) for LTBI diagnosis in PLWHAs.

OBJECTIVE: To determine the prevalence and predictors of positive TSTs in PLWHAs in Orel Oblast.

METHODS: A total of 150 consenting PLWHAs being followed up at the AIDS Center were administered a TST and a questionnaire for risk factors for LTBI. A positive TST result was defined as ≥5 mm induration.

RESULTS: Of the 150 subjects, 67% were male and 74% were aged <30 years. Of the PLWHAs tested, 26% had a positive TST result, while among PLWHAs with CD4+ >500 cells/ml, 36% were TST-positive. TST positivity varied inversely with CD4+ cell count. Among PLWHAs with a history of injection drug use, the primary risk factor for HIV, 29 (31.9%) were positive.

CONCLUSIONS: A high proportion of tested PLWHAs had a positive TST and could benefit from preventive therapy (PT) to reduce the risk of TB. A TB control programme in Russia should therefore include TST screening among PLWHAs and PT, besides active TB case finding and treatment.
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Keywords: HIV; latent tuberculosis infection; tuberculin skin test

Document Type: Regular Paper

Affiliations: 1: Division of TB Elimination, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA; US Civilian Research Development Foundation, Moscow, Russia 2: Orel Center for Prevention of AIDS and Infectious Diseases, TB Dispensary and Ministry of Health, Orel, Russia 3: Division of TB Elimination, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA 4: Emory University School of Medicine, Atlanta, Georgia, USA

Publication date: 2009-07-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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