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Free Content Comparative study of RT23 and Merieux tuberculin tested among healthy volunteers

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SETTING: Several studies have indicated considerable variability in the biological results of different tuberculin preparations in different geographical areas or even within a single region.

OBJECTIVE: To compare the biological potency of two different tuberculins.

DESIGN: We performed simultaneous testing with RT23 and Merieux tuberculin in a group of 546 Police Academy students in Athens to compare reactions to both tuberculins. The students were divided into three groups according to their year of training; the participants in each group were tested using the Mantoux method simultaneously with the two tuberculins in different concentrations.

RESULTS: Using a 10 mm cut-off point for a positive tuberculin skin test, positive reactions to RT23 and Merieux were highly correlated. No statistically significant difference was established. The results indicated significant superiority of the size of the reaction with RT23 tuberculin (P = 0.014).

CONCLUSIONS: Both tuberculins appear to have equivalent potency, with RT23 more frequently producing reactions of larger sizes.

Keywords: RT23; bacillus Calmette-Guérin (BCG); potency; purified protein derivative; tuberculin Merieux; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Tuberculosis Department, Resistant Tuberculosis Unit, ‘Sotiria’ General Regional Chest Hospital of Athens, Athens, Greece 2: School of Nursing, Intensive Care Unit, Trauma Hospital ‘KAT’, University of Athens, Kifissia, Athens, Greece 3: Pulmonary Disease Department, University of Thessalia, Larissa, Greece

Publication date: March 1, 2009

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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