Authors: Cecchini, D.; Ambrosioni, J.; Brezzo, C.; Corti, M.; Rybko, A.; Perez, M.; Poggi, S.; Ambroggi, M.

Source: The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 2, February 2009 , pp. 269-271(3)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

We performed a retrospective comparison of cerebrospinal fluid (CSF) characteristics and drug susceptibility profile in human immunodeficiency virus (HIV) infected and non-infected patients with a diagnosis of tuberculous meningitis. HIV-infected patients had a higher frequency of non-inflammatory CSF (absence of pleocytosis) and of infection by multidrug-resistant strains of Mycobacterium tuberculosis. Protein CSF levels were lower in HIV-infected patients, while and glucose concentration was similar in both groups. Hospital mortality was significantly higher in HIV-infected patients (63.3% [64/101] vs. 17.5% [7/40]).

Keywords: tuberculous meningitis; HIV; multidrug resistance; cerebrospinal fluid; pleocytosis

Document Type: Short communication

Affiliations: 1: Hospital Francisco J Muñiz, Buenos Aires, Argentina

Publication date: 2009-02-01

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• The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

  Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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