Authors: Kilicaslan, Z.¹; Kiyan, E.¹; Kucuk, C.²; Kumbetli, S.³; Sarimurat, N.²; Ozturk, F.⁴; Yapici, D.⁵; Al, S.⁶; Erboran, T.⁷; Iliksu, N.⁸

Source: The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 1, January 2009 , pp. 93-98(6)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

SETTING: Seven public tuberculosis (TB) dispensaries in Istanbul, Turkey.

OBJECTIVE: To investigate the risk of active TB among adult household contacts (age ≥ 15 years) of newly diagnosed sputum smear-positive pulmonary TB (PTB) cases in Istanbul.

DESIGN: A retrospective analysis of adult household contacts of 1570 pulmonary TB cases registered at seven TB dispensaries in Istanbul between 1997 and 2000.

RESULTS: A total of 6188 household contacts (mean contact/index case: 3.9) were included in the study, of whom 4114 (67%) were aged ≥15 years (mean contact/index case: 2.6); 3310 (80.5%) of these participated in a contact investigation. The mean duration of follow-up was 2.2 years (range 1-4 years); 222 active TB cases (rate 5.4%, 95%CI 5.2-5.6) were detected, 171 within the first year. The incidence of active TB was 2491/100 000 (3555/100 000 in the 15-34 year age group and 1195/100 000 in the ≥35 year age group, P < 0.0001). Rates of active TB were highest in the 15-24 year (8.5%) and 25-34 year (6.5%) age groups.

CONCLUSION: The incidence of active TB among adult household contacts of sputum smear-positive PTB cases was high. This high incidence justifies the prescription of chemopropylaxis not only for children but also for all contacts, especially those aged between 15 and 34 years.

Keywords: contact investigation; household contact; pulmonary tuberculosis; smear-positive cases

Document Type: Regular paper

Affiliations: 1: Department of Respiratory Diseases, Istanbul Medical School, Istanbul University, Istanbul, Turkey 2: Sehremini Tuberculosis Dispensary, Istanbul, Turkey 3: Eyup Tuberculosis Dispensary, Istanbul, Turkey 4: Umraniye Tuberculosis Dispensary, Istanbul, Turkey 5: Besiktas Tuberculosis Dispensary, Istanbul, Turkey 6: Bagcilar Tuberculosis Dispensary, Istanbul, Turkey 7: Kadikoy Tuberculosis Dispensary, Istanbul, Turkey 8: Uskudar Tuberculosis Dispensary, Istanbul, Turkey

Publication date: 2009-01-01

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• The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

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