Authors: Agrawal, D.¹; Udwadia, Z.F.¹; Rodriguez, C.²; Mehta, A.¹

Source: The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 1, January 2009 , pp. 79-83(5)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

SETTING: Tertiary referral centre, private hospital, Mumbai, India.

OBJECTIVE: To analyse the incidence of fluoroquinolone (FQ) resistant Mycobacterium tuberculosis (TB) in our laboratory from 1995 to 2004.

DESIGN: Retrospective review and analysis of the drug susceptibility test records of all M. tuberculosis culture-positive samples from our Microbiology Department from 1995 to 2004.

RESULTS: FQ resistance has increased exponentially in our laboratory, from 3% in 1996 to 35% in 2004. The incidence of multidrug-resistant tuberculosis has also increased during the same period, from 33% in 1995 to 56% in 2004.

CONCLUSION: The incidence of FQ-resistant M. tuberculosis is gradually increasing to alarming levels. This may be due to widespread use of this vital group of drugs in the treatment of community-acquired infections. We urge that these broad spectrum antibiotics be used judiciously, and ideally be reserved for treatment of resistant TB in TB-endemic areas.

Keywords: fluoroquinolones; TB; resistance; India; drug-resistant TB

Document Type: Regular paper

Affiliations: 1: Department of Respiratory Medicine, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India 2: Department of Microbiology, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India

Publication date: 2009-01-01

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• The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

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