Authors: Hanif, M.; Malik, S.; Dhingra, V.K.

Source: The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 1, January 2009 , pp. 74-78(5)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

SETTING: State TB Demonstration Centre, Delhi, India.

OBJECTIVE: To obtain a baseline estimate of the prevalence of multidrug-resistant tuberculosis (MDR-TB) among previously treated tuberculosis (TB) cases at the State Tuberculosis Centre in 2006.

DESIGN: A retrospective study. Drug susceptibility data of 5252 previously treated patients tested at this centre were analysed.

RESULTS: Of 2880 Mycobacterium tuberculosis isolates from previously treated cases, 1498 (52%) were resistant to one or more anti-tuberculosis drugs, of which 47.1% were MDR. Resistance to isoniazid was observed in all resistant isolates, followed by resistance to rifampicin in 1357 (47.1%), streptomycin in 403 (14.2%) and ethambutol in 107 (3.72%). A significantly higher rate of resistance, including MDR, was observed among treatment failures compared to relapses and defaulters.

CONCLUSION: A very high proportion of drug-resistant cases had MDR besides resistance to two or more drugs. This proportion was significantly higher among treatment failures compared to relapses and treatment after default cases, underlining the need for early identification of treatment failure by early referral for culture and drug susceptibility testing, and initiation of appropriate treatment.

Keywords: tuberculosis; drug resistance; previously treated

Document Type: Regular paper

Affiliations: 1: New Delhi Tuberculosis Centre, State Tuberculosis Demonstration Centre, New Delhi, India

Publication date: 2009-01-01

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• The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

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