Authors: Lomtadze, N.¹; Aspindzelashvili, R.²; Janjgava, M.²; Mirtskhulava, V.³; Wright, A.⁴; Blumberg, H.M.⁵; Salakaia, A.²

Source: The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 1, January 2009 , pp. 68-73(6)

Publisher: International Union Against Tuberculosis and Lung Disease

Abstract:

SETTING: Multidrug-resistant tuberculosis (MDR-TB, defined as resistance to at least isoniazid and rifampicin) has emerged as a serious global public health problem, especially in the former Soviet republics. The extent of the problem in Georgia has been incompletely defined.

OBJECTIVE: To determine the prevalence and risk factors for MDR-TB in Georgia.

DESIGN: A population-based study was carried out between July 2005 and May 2006.

RESULTS: Of 1314 patients with acid-fast bacilli smear- and culture-positive pulmonary tuberculosis (TB), 799 (60.8%) were newly diagnosed patients and 515 (39.2%) had been treated previously. Overall, 733 (56%) patients had resistance to at least one anti-tuberculosis drug and 195 (15%) had MDR-TB. Patients who had been treated previously for TB were significantly more likely to have MDR-TB than newly diagnosed patients (141/515 [27.4%] vs. 54/794 [6.8%], OR 5.27, 95%CI 3.75-7.41). In multivariate analysis, previous TB treatment (aOR 5.47, 95%CI 3.87-7.74) and female sex (aOR1.58, 95%CI 1.02-2.32) were independent risk factors for the presence of MDR-TB.

CONCLUSIONS: Drug-resistant TB, including MDR-TB, has emerged as a major public health problem in Georgia. Further TB control efforts need to be implemented to prevent the development of new cases of MDR-TB and to treat existing patients with MDR-TB.

Keywords: multidrug-resistant tuberculosis; MDR-TB; Drug Resistance Survey; Georgia

Document Type: Regular paper

Affiliations: 1: National Centre for Tuberculosis and Lung Diseases/National Tuberculosis Programme, Tbilisi, Georgia; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA 2: National Centre for Tuberculosis and Lung Diseases/National Tuberculosis Programme, Tbilisi, Georgia 3: National Centre for Tuberculosis and Lung Diseases/National Tuberculosis Programme, Tbilisi, Georgia; and Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA 4: World Health Organization, Stop TB Department, Geneva, Switzerland 5: Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA

Publication date: 2009-01-01

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• The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

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