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Free Content Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia [Short communication]

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Abstract:

Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the −2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3–5.5).

Keywords: Africa; CCL2; Zambia; polymorphism; tuberculosis

Document Type: Short Communication

Affiliations: 1: Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands 2: St. Francis Hospital, Katete, Zambia 3: Department of Medical Microbiology, Vlietland Hospital, Schiedam, The Netherlands 4: Centre for Infectious Diseases Control, Epidemiology and Surveillance, National Institute of Public Health and the Environment, Bilthoven, The Netherlands 5: National Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment, Bilthoven, The Netherlands

Publication date: December 1, 2008

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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