@article {Moreno:2008:1027-3719:1393,
title = "Incidence and risk factors for tuberculosis in HIV-positive subjects by HAART status",
journal = "The International Journal of Tuberculosis and Lung Disease",
parent_itemid = "infobike://iuatld/ijtld",
publishercode ="iuatld",
year = "2008",
volume = "12",
number = "12",
publication date ="2008-12-01T00:00:00",
pages = "1393-1400",
itemtype = "ARTICLE",
issn = "1027-3719",
eissn = "1815-7920",
url = "https://www.ingentaconnect.com/content/iuatld/ijtld/2008/00000012/00000012/art00011",
keyword = "TB-HIV co-infection, injecting drug users, tuberculosis, HAART",
author = "Moreno, S. and Jarrin, I. and Iribarren, J. A. and Perez-El{\’ı}as, M. J. and Viciana, P. and Parra, J. and Gomez-Sirvent, J. L. and Lopez-Aldeguer, J. and Gutierrez, F. and Blanco, J. R. and Vidal, F. and Leal, M. and Rodr{\’ı}guez Arenas, M. A. and del Amo, J. and CoRIS-MD",
abstract = "OBJECTIVE: To estimate incidence rates and risk factors for tuberculosis (TB) in human immunodeficiency virus seroprevalent subjects.METHODS: Multicentre, hospital-based cohort study of patients presenting to 10 Spanish hospitals from 1 January 1997 to 31 December 2003. Poisson regression was used and highly active antiretroviral treatment (HAART) was modelled as a time-dependent covariate.RESULTS: A total of 4268 patients were followed for a median of 3.8 years; 221 TB cases were diagnosed over 16464 person-years (py). TB rates were higher in HAART-na{\"ı}ve subjects (1.56 per 100 py, 95%CI 1.361.79) than those on HAART (0.5/100 py, 95%CI 0.310.80). Among HAART-na{\"ı}ves, TB risk factors were: being male, being an injecting drug user (IDU) (RR 2.01, 95%CI 1.283.16), having low CD4 counts (P P P CONCLUSIONS: HAART was associated with lower TB rates, and TB risk factors differed according to whether or not patients had received HAART. To further reduce TB rates, additional strategies are needed, such as timely access and adherence to HAART, especially in IDUs.",
}