Risk factors for multidrug-resistant tuberculosis in Hong Kong
OBJECTIVE: To explore the risk factors for MDR-TB in Hong Kong.
DESIGN: MDR-TB patients treated between 1999 and 2003 were compared with non-MDR-TB patients by stratification of previous anti-tuberculosis treatment.
RESULTS: One hundred and fifty-six MDR-TB patients, including 93 with and 63 without a previous history of anti-tuberculosis treatment, were identified. Among the 322 non-MDR-TB controls, respectively 192 and 130 patients did and did not have a previous history of anti-tuberculosis treatment. Using logistic regression analysis, non-permanent residents (OR 6.85, 95%CI 1.38–34.09), frequent travel (OR 2.48, 95%CI 1.07–5.74) and younger age were found to be independent predictors of MDR-TB in previously treated patients, whereas living on financial assistance just failed to reach statistical significance (OR 2.75, 95%CI 0.98–7.68, P = 0.05). In the treatment-naïve group, despite significant differences in baseline characteristics among MDR-TB and non-MDR-TB patients, no independent predictor variables could be identified.
CONCLUSION: In Hong Kong, non-permanent residents, frequent travel and young age were independent predictors of MDR-TB among previously treated patients.
Document Type: Regular Paper
Affiliations: 1: Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China 2: Tuberculosis and Chest Unit, Grantham Hospital, Hong Kong, China 3: Tuberculosis Reference Laboratory, Public Health Laboratory Centre, Centre for Health Protection, Hong Kong SAR, China
Publication date: 2008-09-01
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