@article {Dubrovina:2008:1027-3719:756,
title = "Drug-resistant tuberculosis and HIV in Ukraine: a threatening convergence of two epidemics?",
journal = "The International Journal of Tuberculosis and Lung Disease",
parent_itemid = "infobike://iuatld/ijtld",
publishercode ="iuatld",
year = "2008",
volume = "12",
number = "7",
publication date ="2008-07-01T00:00:00",
pages = "756-762",
itemtype = "ARTICLE",
issn = "1027-3719",
eissn = "1815-7920",
url = "https://www.ingentaconnect.com/content/iuatld/ijtld/2008/00000012/00000007/art00012",
keyword = "tuberculosis, HIV, Ukraine, MDR-TB",
author = "Dubrovina, I. and Miskinis, K. and Lyepshina, S. and Yann, Y. and Hoffmann, H. and Zaleskis, R. and Nunn, P. and Zignol, M.",
abstract = "OBJECTIVE: To investigate anti-tuberculosis (TB) drug resistance rates in Donetsk Oblast, Ukraine, and to explore the association between the epidemics of human immunodeficiency virus (HIV) and multidrug-resistant TB (MDR-TB).METHODS: All consecutive newly diagnosed and previously treated patients with sputum smear-positive TB presenting to all TB units in Donetsk Oblast over 12 months were invited to take part in the study. A total of 1293 and 203 patients with TB were tested for HIV and MDR-TB in the civilian and penitentiary sectors, respectively.RESULTS: Of those enrolled for the study, 307 were HIV-positive, 379 had MDR-TB, and 97 had MDR-TB and HIV co-infection. MDR-TB rates in the civilian sector were respectively 15.5% (95%CI 13.117.8) and 41.5% (95%CI 36.446.5) in newly diagnosed and previously treated TB patients. Among prisoners, MDR-TB rates were 21.8% (95%CI 12.431.2) in new cases and 52.8% (95%CI 43.961.7) in previously treated TB cases. HIV status was significantly associated with MDR-TB (OR 1.7, 95%CI 1.32.3).CONCLUSIONS: High MDR-TB rates and a positive association between MDR-TB and HIV epidemics were found in Donetsk Oblast. Urgent measures to improve HIV prevention, control of drug-resistant TB and collaboration between HIV and TB control activities need to be implemented without further delay.",
}