Free Content Risk factors for delay in the diagnosis and treatment of tuberculosis at a referral hospital in Rwanda

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Abstract:

SETTING: Kigali University Hospital, the main referral centre for TB in Rwanda.

OBJECTIVE: To evaluate delays in the diagnosis and treatment of tuberculosis (TB) and associated risk factors.

DESIGN: Prospective data collection of patients treated for pulmonary TB (PTB) or extra-pulmonary TB (EPTB) between June and September 2006.

RESULTS: Of 104 patients with a mean age of 35 years (range 17–84) recruited into the study, 62% were HIV-positive. EPTB was diagnosed in 60 cases. The median total, health care and patient delays were respectively 57, 28 and 25 days. The health system delay before referral was significantly longer than the delay at our institution (18 vs. 6 days, P < 0.0001). Risk factors for a longer health system delay at our institution were smear-negative PTB or EPTB (OR 5.12) and a trial of antibiotics (OR 2.96). The latter was also found to significantly prolong total delay (OR 2.85), as did rural residence (OR 4.86). No significant association was found between patient delay and age, sex, profession or health insurance status.

CONCLUSION: Smear-negative PTB and EPTB were associated with longer health system delays. A trial of antibiotics significantly increased the health system delay. Its use, recommended by the World Health Organization in case of smear-negative TB and EPTB in developing countries, needs validation at the tertiary health care level.

Keywords: Rwanda; antibiotic trial; diagnostic delay; reference level; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Department of Internal Medicine; Belgian Technical Cooperation, Kigali University Hospital, Kigali, Rwanda 2: Department of Internal Medicine, Kigali University Hospital, Kigali, Rwanda 3: National Tuberculosis and Leprosy Control Programme, Ministry of Health, Kigali, Rwanda 4: Belgian Technical Cooperation, Kigali University Hospital, Kigali, Rwanda 5: Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium 6: Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium; Tropical Diseases Ward, University Hospital Antwerp, Belgium

Publication date: April 1, 2008

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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