Skip to main content

Free Content Estimating tuberculosis case mortality in England and Wales, 2001–2002

Download Article:
 Download
(PDF 116.3 kb)
 

Abstract:

SETTING: England and Wales, 2001–2002.

OBJECTIVE: To obtain a more accurate estimate of tuberculosis (TB) case fatality within 12 months of starting treatment or notification among TB cases reported to the national surveillance system.

METHODS: Records of deaths for all TB cases reported to the national surveillance system were identified using linkage to two other sources of mortality information: the National Health Service (NHS) central register and death registrations from the Office for National Statistics (ONS). These data were compared to reports of deaths ascertained by national TB surveillance through treatment outcome monitoring. Capture-recapture methodology was used to estimate any remaining unascertained deaths for the final calculation of the case fatality rate (CFR).

RESULTS: In total, 1169 deaths (95%CI 1140–1224) were identified among 13176 cases (CFR 8.9%, 95%CI 8.7–9.3%). Data linkage with the NHS central register and death registrations from the ONS identified a further 255 deaths not recorded by national TB surveillance. Capture-recapture estimated 61 (95%CI 32–116) unascertained deaths.

CONCLUSION: Mortality among TB cases is underestimated by national TB surveillance. Real-time data linkage between case reports and death registrations would allow a more accurate and timely estimate of TB mortality.

Keywords: capture-recapture; mortality; surveillance; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Department of Respiratory Diseases, Health Protection Agency Centre for Infections, London, UK 2: Department of Immunisation, Health Protection Agency Centre for Infections, London, UK 3: Department of Statistics Modelling & Bioinformatics, Health Protection Agency Centre for Infections, London, UK

Publication date: March 1, 2008

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • Ingenta Connect is not responsible for the content or availability of external websites

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Partial Open Access Content
Partial Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more