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Free Content External quality control of Mycobacterium tuberculosis drug susceptibility testing: results of two rounds in endemic countries [Short Communication]

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Abstract:

SETTING: Quality assurance for the World Health Organization (WHO)/International Union Against Tuberculosis and Lung Disease (The Union) global tuberculosis (TB) drug resistance surveillance programme.

OBJECTIVE: To monitor the quality of drug susceptibility testing (DST) in different countries.

METHODS: In 2002–2003 and 2005–2006, 20 Mycobacterium tuberculosis strains were sent by the WHO/Union Supranational Reference Laboratory of Rome to TB reference laboratories in Albania, Bahrain, Kosovo, Mozambique, Oman, Qatar and Turkey for external quality control (EQC).

RESULTS: In 2002–2003, the specificity, sensitivity, efficiency, reproducibility and predictive values for resistance/susceptibility were ≥90% for streptomycin (SM), isoniazid (INH) and ethambutol (EMB). In 2005–2006, all statistical values were ≥96% for SM, INH, rifampicin and EMB.

CONCLUSION: EQC improved the quality of M. tuberculosis DST in the participating countries.

Keywords: Mycobacterium tuberculosis; WHO/Union Supranational Reference Laboratories; drug susceptibility testing; external quality control

Document Type: Short Communication

Affiliations: 1: Istituto Superiore di Sanità, Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Rome, Italy 2: San Raffaele Scientific Institute, Emerging Bacterial Pathogens, Milan, Italy 3: Fondazione S. Maugeri, WHO Collaborating Centre for TB and Lung Diseases, Tradate, Italy 4: World Health Organization, Stop TB Department, Geneva, Switzerland 5: University Hospital of Lung Diseases, Tirana, Albania 6: National Reference Laboratory, Manama, Bahrain 7: National Institute of Public Health, Prishtina, Kosovo 8: Laboratorio National de Referencia da TB/Lepra, Maputo, Mozambique 9: Central Public Health Oman, Muscat, Oman 10: Department of Laboratory Medicine and Pathology, Doha, Qatar 11: National Reference Laboratory, Ankara, Turkey

Publication date: February 1, 2008

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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