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Free Content Tolerability of anti-tuberculosis treatment and HIV serostatus

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Abstract:

SETTING: Tuberculosis (TB) is frequent in human immunodeficiency virus (HIV) infected patients, but its treatment is hampered by adverse events and paradoxical reactions.

OBJECTIVE: To examine the impact of HIV infection and other factors on the risk and spectrum of adverse events related to anti-tuberculosis treatment in a prospective cohort study conducted between January 2003 and August 2004.

RESULTS: Of 105 patients treated for TB, 30 were HIV-infected. The overall incidence of adverse events was 122.5 ± 18.5 per 100 patient-years (py) and the incidence of severe adverse events was 45.2 ± 11.3/100 py. Age >50 years (OR 2.2, 95%CI 1.01–4.8, P = 0.046) and HIV infection (OR 3.9, 95%CI 2.1–7.5, P < 0.001) were independently associated with a higher risk of adverse events. Hepatitis (30.5/100 py) and neuropathy (28.6/100 py) were the most frequent adverse events. Hepatitis C virus infection was associated with hepatitis (OR 4.2, 95%CI 1.2–15.0, P = 0.028) and neuropathy with HIV infection (OR 3.8, 95%CI 1.1–13.7, P = 0.040).

CONCLUSION: Adverse reactions to anti-tuberculosis drugs are frequent. HIV infection and age >50 years are factors associated with such reactions, while hepatitis C virus infection is a risk factor for hepatitis.

Keywords: HIV; drug tolerability; paradoxical reaction; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Service de Maladies Infectieuses et Tropicales, Hôpital de la Pitié-Salpétrière, Paris, France 2: Unité INSERM 720 et Université Pierre et Marie Curie, Paris, France

Publication date: 2007-11-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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