Free Content Utility of QuantiFERON-TB Gold in-tube testing for latent TB infection in HIV-infected individuals

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Abstract:

SETTING: Urban inner city human immunodeficiency virus (HIV) clinic.

OBJECTIVE: To evaluate tuberculin skin testing (TST) and QuantiFERON-TB Gold (QFT-G) testing in an HIV-infected population relative to the presence of risk factors for latent tuberculosis infection (LTBI).

DESIGN: Cross-sectional analysis of the response of a whole blood gamma interferon release assay to early secreted antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) antigens and TST relative to known risk factors for LTBI.

RESULTS: Of 207 subjects enrolled, four were excluded due to missing data and three specimens yielded discordant results. Ten specimens were indeterminate due to inadequate response to mitogen. All indeterminate results occurred in subjects with CD4 counts <200 cells/mm3. Eleven QFT-G results and 13 TST results were positive. The concordance between TST and QFT-G was poor (κ 0.38). QFT-G results were more likely than TST to be associated with risk factors for LTBI.

CONCLUSIONS: QFT-G, but not TST, showed a statistically significant association between the number of risk factors for LTBI and a positive result (OR 1.6). QFT-G testing may be more useful than TST in individuals with HIV infection.

Keywords: ELISA; HIV; QuantiFERON; interferon; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, New York, USA 2: AIDS Center, Mount Sinai School of Medicine, New York, New York, USA 3: Division of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA 4: Wyeth, Vaccine Research, Pearl River, New York, USA 5: School of Public Health, New York Medical College, Valhalla, New York, USA 6: Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York, USA

Publication date: November 1, 2007

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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