Genotyping of Mycobacterium tuberculosis over two periods: a changing scenario for tuberculosis transmission
DESIGN: A population-based molecular study was conducted using standard restriction fragment length polymorphism IS6110 typing that included all patients with bacteriologically confirmed TB living in the Zaragoza area from 2001 to 2004. The current situation was compared with that described in a previous study from 1993 to 1995.
RESULTS: A total of 454 Mycobacterium tuberculosis isolates were genotyped; 239 (52.6%) were grouped in 45 clusters composed of 2 to 85 isolates. Independent risk factors for clustering were identified. The main differences with the previous study were the increase of TB cases among immigrants, a decrease in HIV-TB co-infected patients and the occurrence of a large TB outbreak involving 85 patients (M. tuberculosis Zaragoza [MTZ] strain).
CONCLUSION: A change in the epidemiological pattern of TB has been observed in the last years. TB transmission is more common among the Spanish-born population, while foreign birth is significantly less associated with clustering. A single epidemic strain caused 18.7% of all TB cases.
Document Type: Regular Paper
Affiliations: 1: Servicio de Microbiología, Hospital Universitario Miguel Servet, Zaragoza, Spain; and Centro de Investigación Biomédica en Red, Enfermedades Respiratorias, Recinto Hospital Joan March, Mallorca, Spain 2: Centro de Investigación Biomédica en Red, Enfermedades Respiratorias, Recinto Hospital Joan March, Mallorca, Spain; and Servicio de Microbiología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
Publication date: 01 October 2007
The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website
- Editorial Board
- Information for Authors
- Subscribe to this Title
- International Journal of Tuberculosis and Lung Disease
- Public Health Action
- Ingenta Connect is not responsible for the content or availability of external websites