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Free Content Micronutrient supplements and mortality of HIV-infected adults with pulmonary TB: a controlled clinical trial

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SETTING: Zomba and Blantyre, Malawi, Africa.

OBJECTIVES: To determine whether daily micronutrient supplementation reduces the mortality of human immunodeficiency virus (HIV) infected adults with pulmonary tuberculosis (TB).

DESIGN: A randomised, controlled clinical trial of micronutrient supplementation for HIV-positive and HIV-negative adults with pulmonary TB. Participants were enrolled at the commencement of chemotherapy for sputum smear-positive pulmonary TB and followed up for 24 months.

RESULTS: A total of 829 HIV-positive and 573 HIV-negative adults were enrolled. During follow-up, 328 HIV-positive and 17 HIV-negative participants died. The proportion of HIV-positive participants who died in the micronutrient and placebo groups was 38.7% and 40.4%, respectively (P = 0.49). Micronutrient supplementation did not reduce mortality (hazard ratio [HR] 0.93, 95%CI 0.75–1.15) among HIV-positive adults.

CONCLUSIONS: Micronutrient supplementation at the doses used in this study does not reduce mortality in HIV-positive adults with pulmonary TB in Malawi.

Keywords: Africa; HIV; TB; malnutrition; micronutrient; mortality

Document Type: Regular Paper

Affiliations: 1: Johns Hopkins Medical Institutions, Baltimore, Maryland, USA 2: Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi 3: Department of Epidemiology and Biostatistics and Tuberculosis Research Unit, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA 4: HIV Unit, Ministry of Health, Malawi, and National TB Control Programme, Lilongwe, Malawi

Publication date: 2007-08-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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