Micronutrient supplements and mortality of HIV-infected adults with pulmonary TB: a controlled clinical trial
Abstract:SETTING: Zomba and Blantyre, Malawi, Africa.
OBJECTIVES: To determine whether daily micronutrient supplementation reduces the mortality of human immunodeficiency virus (HIV) infected adults with pulmonary tuberculosis (TB).
DESIGN: A randomised, controlled clinical trial of micronutrient supplementation for HIV-positive and HIV-negative adults with pulmonary TB. Participants were enrolled at the commencement of chemotherapy for sputum smear-positive pulmonary TB and followed up for 24 months.
RESULTS: A total of 829 HIV-positive and 573 HIV-negative adults were enrolled. During follow-up, 328 HIV-positive and 17 HIV-negative participants died. The proportion of HIV-positive participants who died in the micronutrient and placebo groups was 38.7% and 40.4%, respectively (P = 0.49). Micronutrient supplementation did not reduce mortality (hazard ratio [HR] 0.93, 95%CI 0.75–1.15) among HIV-positive adults.
CONCLUSIONS: Micronutrient supplementation at the doses used in this study does not reduce mortality in HIV-positive adults with pulmonary TB in Malawi.
Document Type: Regular Paper
Affiliations: 1: Johns Hopkins Medical Institutions, Baltimore, Maryland, USA 2: Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi 3: Department of Epidemiology and Biostatistics and Tuberculosis Research Unit, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA 4: HIV Unit, Ministry of Health, Malawi, and National TB Control Programme, Lilongwe, Malawi
Publication date: 2007-08-01
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