Free Content Pregnancies complicated by multidrug-resistant tuberculosis and HIV co-infection in Durban, South Africa [Short Communication]

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SETTING: Tertiary hospitals in KwaZulu Natal, South Africa.

OBJECTIVE: To study the impact of multidrug-resistant tuberculosis (MDR-TB) and human immunodeficiency virus-1 (HIV-1) co-infection during pregnancy on maternal and perinatal outcome.

DESIGN: Prospective study performed between 1996 and 2001. Symptomatic pregnant women were investigated for TB. Those with confirmed MDR-TB were reported on.

RESULTS: Three of five pregnant women with MDR-TB were HIV-1 co-infected. One woman decided to terminate the pregnancy and one experienced pre-term labour. Two neonates had features of growth restriction.

CONCLUSION: Management of pregnant women with MDR-TB in an HIV-endemic area is possible in developing countries.

Keywords: HIV-1; maternal and perinatal outcomes; multidrug-resistant tuberculosis

Document Type: Short Communication

Affiliations: 1: Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella, Durban, KwaZulu Natal, South Africa 2: Neonatal Unit, New Cross Hospital, Wolverhampton, West Midlands, UK 3: Women's Health and HIV Research Unit, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella, KwaZulu Natal, South Africa 4: King George V Hospital, Durban, KwaZulu Natal, South Africa

Publication date: June 1, 2007

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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