Determinants of chronic obstructive pulmonary disease in Chinese patients in Hong Kong
Abstract:BACKGROUND: The prevalence of chronic obstructive pulmonary disease (COPD) is rising in many parts of the world. This is a study of risk factors for COPD in Chinese patients in Hong Kong.
DESIGN: Case-control study matched by sex and age (±5 years).
METHODS: A total of 289 consecutive patients with COPD were recruited from out-patient clinics while healthy controls were recruited from two sources: random population and community centres for senior citizens. All patients and controls underwent a questionnaire-based interview and spirometry.
RESULTS: The mean ages of COPD patients and controls were 71.1 ± 9.4 and 67.5 ± 9.3 years, respectively. The male to female ratio of COPD patients was 5 to 1. Smoking was found to be the most important determinant for COPD, followed by poor education and low body mass index adjusted for confounders. A dose-dependent relationship was found between the risk of COPD and pack-years smoked. Place of birth, exposure to environmental tobacco smoke and a history of asthma and tuberculosis were not associated with increased risk of COPD.
CONCLUSION: Despite a progressive reduction in prevalence, smoking remains the most important predictor of COPD in Hong Kong. Greater anti-smoking efforts are warranted.
Document Type: Regular Paper
Affiliations: 1: Respiratory Division, Department of Medicine, The University of Hong Kong, Hong Kong, China 2: Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hospital Authority, Hong Kong, China 3: Ruttonjee Hospital, Hospital Authority, Hong Kong, China 4: Kwong Wah Hospital, Hospital Authority, Hong Kong, China 5: Tuen Mun Hospital, Hospital Authority, Hong Kong, China 6: Caritas Medical Centre, Hospital Authority, Hong Kong, China 7: Haven of Hope Hospital, Hospital Authority, Hong Kong SAR, China
Publication date: 2007-05-01
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