Free Content

Impact of short-term exposure to fluoroquinolones on ofloxacin resistance in HIV-negative patients with tuberculosis

Authors: Park, I-N.1; Hong, S-B.1; Oh, Y-M.1; Lim, C-M.1; Lee, S. D.1; Lew, W. J.2; Koh, Y.1; Kim, W. S.1; Kim, D. S.1; Kim, W. D.1; Shim, T. S.1

Source: The International Journal of Tuberculosis and Lung Disease, Volume 11, Number 3, March 2007 , pp. 319-324(6)

Publisher: International Union Against Tuberculosis and Lung Disease

Buy & download fulltext article:

Free content The full text is free.

View now:
PDF 142.8kb 

Abstract:

SETTING: Seoul, Korea, a country with an intermediate tuberculosis (TB) burden and low prevalence of human immunodeficiency virus (HIV) infection.

OBJECTIVES: To determine the frequency of ofloxacin (OFX) resistance in Mycobacterium tuberculosis, and to assess whether short-term use of fluoroquinolones (FQNs) induces ofloxacin-resistant M. tuberculosis.

DESIGN: The subject cohort consisted of 2788 patients with culture-confirmed TB with drug susceptibility testing data; only four were HIV-positive. The patients were divided into two groups: those who were or were not recently exposed to FQNs.

RESULTS: Of the 2788 isolates, the rates of OFX resistance were 1.1% and 8.5% in initially treated and retreated patients, respectively (P < 0.05). Of the 94 OFX-resistant isolates, 83 (88.3%) were multidrug-resistant (MDR). There was no difference in rates of OFX resistance throughout the study period, or between the FQN-exposed (1/39, 2.6%) and control groups (93/2749, 3.4%). The median duration of FQN treatment was 7 days (range 1–47 days). One OFX-resistant isolate in the FQN-exposed group was MDR.

CONCLUSION: The rate of OFX-resistant M. tuberculosis was low and stationary throughout the study period in Korea. Most OFX resistance was accompanied by MDR, and the frequency of OFX-resistant M. tuberculosis was low in subjects taking short-term FQNs.

Keywords: drug resistance; fluoroquinolones; multidrug resistance; tuberculosis

Document Type: Regular Paper

Affiliations: 1: Division of Pulmonary & Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea 2: Korean Institute of Tuberculosis, Seoul, Korea

Publication date: March 1, 2007

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • ingentaconnect is not responsible for the content or availability of external websites
Related content

Tools

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page