Risk factors associated with default among new pulmonary TB patients and social support in six Russian regions
OBJECTIVE: To identify risk factors for default and to evaluate possible impact of social support.
METHODS: Retrospective study of new pulmonary smear-positive and smear-negative TB patients registered during the second and third quarters of the 2003. Data were analysed in a case-control study including default patients as cases and successfully treated patients as controls, using multivariate logistic regression modelling.
RESULTS: A total of 1805 cases of pulmonary TB were enrolled. Default rates in the regions were 2.3–6.3%. On multivariate analysis, risk factors independently associated with default outcome included: unemployment (OR 4.44; 95%CI 2.23–8.86), alcohol abuse (OR 1.99; 95%CI 1.04–3.81), and homelessness (OR 3.49; 95%CI 1.25–9.77). Social support reduced the default outcome (OR 0.13; 95%CI 0.06–0.28), controlling for age, sex, region, residence and acid-fast bacilli (AFB) smear of sputum.
CONCLUSION: Unemployment, alcohol abuse and homelessness were associated with increased default outcome among new TB patients, while social support for TB patients reduced default. Further prospective randomised studies are necessary to evaluate the impact and to determine the most cost-effective social support for improving treatment outcomes of TB in patients in Russia, especially among populations at risk of default.
Document Type: Regular Paper
Affiliations: 1: Office of the Special Representative of the World Health Organization Director-General, Russia, Moscow, Russia 2: Research Institute of Phthisiopulmonology, Sechenov Moscow Medical Academy, Samara, Russia 3: Samara State Medical University, Division of TB and Lung Diseases, Samara, Russia
Publication date: 2007-01-01
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