Sequence variations in the MBL gene and their relationship to pulmonary tuberculosis in the Chinese Han population
Abstract:SETTING: The mannan binding lectin (MBL) gene is thought to play a role in human innate immune response to tuberculosis (TB) infection.
OBJECTIVE: To investigate the possible association between MBL sequence variants and TB infection in the Chinese Han population.
DESIGN: A total of 152 male pulmonary tuberculosis (PTB) patients and 293 healthy male subjects were recruited. Six MBL single nucleotide polymorphisms (SNPs) (A/B, A/C, A/D, H/L, Y/X and P/Q) were genotyped and haplotyped using the combined analysis of polymerase chain reaction using sequence-specific primers (PCR-SSP) and the PCR-sequence specific oligonucleotide probe (PCR-SSOP) assay. The genotype and haplotype frequencies were compared between TB cases and controls using an unconditional logistic regression model.
RESULTS: Neither the genotypes nor the haplotypes of the five loci were significantly associated with the disease when considered individually. After the haplotypes were regrouped, however, the XB haplotype group coding for diminished MBL levels was present at a significantly higher frequency in the patients compared with the YA group (OR 1.57, 95%CI 1.02–2.41, P < 0.05).
CONCLUSION: No convincing evidence of association between MBL sequence variants and PTB was observed individually, although the low-producing XB haplotype group may serve as a minor risk factor for PTB infection in the male Chinese Han population.
Document Type: Regular Paper
Affiliations: 1: Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China 2: Department of Biochemistry, Beijing Institute of Basic Medical Sciences, Beijing, China 3: Department of Public Health, Erasmus Medical Centre, University Medical Center, Rotterdam, The Netherlands
Publication date: 2006-10-01
The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
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