If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Free Content A population-based study of risk factors for drug-resistant TB in British Columbia

 Download
(PDF 124.3kb)
 
Download Article:

Abstract:

SETTING: Provincial tuberculosis (TB) services, British Columbia, Canada.

OBJECTIVE: To investigate risk factors associated with resistance to anti-tuberculosis drugs in British Columbia and to determine if there are differences in risk factor characteristics among different resistance categories.

DESIGN: Using population-based data from provincial TB services, all patients with positive culture for Mycobacterium tuberculosis from 1990 to 2001 were identified and included in the study. Logistic regression analyses were performed to assess risk factors for drug resistance.

RESULTS: Among 3041 eligible TB cases, 295 (10%) were found to be drug-resistant. Significant risk factors for resistance were younger age, foreign birth, ethnicity, reactivated TB and place of initial diagnosis. Foreign-born subjects (OR 3.18, 95%CI 2.26–4.49) were three times more likely to present with resistance than Canadian-born subjects. Among ethnic groups, Chinese (OR 2.32, 95%CI 1.51–3.57), South-East Asian (OR 2.92, 95%CI 1.88–4.52) and Other Asian subjects (OR 4.40, 95%CI 2.77–7.01) were 2–4 times more likely to present with resistance than Caucasians. Reactivated cases (OR 2.69, 95%CI 1.91–3.77) were three times as likely to have resistance as new cases.

CONCLUSION: These results document and quantify the risk of drug-resistant disease in a large population-based cohort, and highlight patient groups who should be identified as at risk for drug-resistant disease in the industrialised world.

Keywords: drug-resistant tuberculosis; multidrug-resistant TB; polyresistant TB; population study; risk factors

Document Type: Regular Paper

Affiliations: 1: Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada; and Division of TB Control, British Columbia Center for Disease Control, Vancouver, British Columbia, Canada 2: Division of TB Control, British Columbia Center for Disease Control, Vancouver, British Columbia, Canada 3: Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada; and Center for Clinical Epidemiology and Evaluation, Vancouver, British Columbia, Canada 4: Center for Clinical Epidemiology and Evaluation, Vancouver, British Columbia, Canada

Publication date: June 1, 2006

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • ingentaconnect is not responsible for the content or availability of external websites
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more