Directly observed treatment for tuberculosis in pharmacies compared with self-administered therapy in Spain
METHODS: Prospective study for DOT (1999–2002) and retrospective study for SAT (1996–1998) in patients at risk for non-adherence (human immunodeficiency virus [HIV] infection, alcoholism, illicit drug use, immigrant or homeless status and/or previous failure to complete). Patients in the DOT programme received medication as out-patients twice a week in pharmacies that supervised adherence and provided socio-sanitary support to patients.
RESULTS: There were 101 and 112 patients in the DOT and SAT groups, respectively. Demographic and clinical characteristics were similar in both groups. Differences were observed in risk factors for non-adherence (more immigrants and fewer intravenous drug users in the DOT vs. the SAT groups; P < 0.05). In the DOT group, 76 patients (75.2%) completed treatment and were cured compared to only 30 patients (26.7%) in the SAT group (P < 0.001). Implementation of DOT increased the cost of treatment by 400€ per patient compared to SAT.
CONCLUSION: In patients at risk for non-adherence, DOT implemented through pharmacy offices was better than SAT; however, completion rates were still low.
Document Type: Regular Paper
Affiliations: 1: Department of Medicine, Faculty of Medicine, University of Valencia, Valencia, Spain; and Department of Pneumology, University General Hospital Consortium, Valencia, Spain 2: Department of Pneumology, University General Hospital Consortium, Valencia, Spain 3: Research Foundation, University General Hospital Consortium, Valencia, Spain; and Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain 4: Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain
Publication date: 2006-02-01
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