Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk [Short Communication]

Authors: Lewis, S.J.¹; Baker, I.¹; Davey Smith, G.¹

Source: The International Journal of Tuberculosis and Lung Disease, Volume 9, Number 10, October 2005 , pp. 1174-1177(4)

Publisher: International Union Against Tuberculosis and Lung Disease

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Abstract:

Several case-control studies performed in populations where the incidence of tuberculosis (TB) is high have examined genetic susceptibility to TB. The Vitamin D receptor (VDR) gene is a good candidate, because it influences immune response, and associations between TaqI and FokI polymorphisms in the VDR gene and pulmonary TB risk have been found. Furthermore, if a relationship between these polymorphisms and TB risk is confirmed this will be important evidence pointing to vitamin D as a potential preventive agent for TB. We carried out a systematic review and meta-analysis, and found that results were inconclusive and studies were underpowered.

Keywords: Vitamin D; tuberculosis; gene; Mendelian randomisation

Document Type: Short communication

Affiliations: 1: Department of Social Medicine, University of Bristol, Bristol, United Kingdom

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