Free Content Neonatal BCG protection against tuberculosis lasts for 20 years in Brazil [Short Communication]

 Download
(PDF 50.6 kb)
 
Download Article:

Abstract:

Bacille Calmette-Guérin (BCG) efficacy against pulmonary disease is highly variable; until very recently there was no evidence of protection after 10 years. In the control arm of a trial of efficacy of revaccination of schoolchildren in Brazil we found substantial protection (39%; 95%CI 9–58) of neonatal BCG against all forms of tuberculosis (TB) 15–20 years after vaccination, much longer than previously believed. This confirms recent findings from an earlier trial, and must be considered in the design of trials of new TB vaccines and in policy decisions based on assumed lack of neonatal BCG protection with time.

Keywords: BCG; neonatal effect; tuberculosis

Document Type: Short Communication

Affiliations: 1: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil 2: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil; and London School of Hygiene and Tropical Medicine, London, United Kingdom 3: Centro de Referência Helio Fraga, FUNASA/Ministry of Health, Rio de Janeiro, Brazil 4: Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brazil; and Funadação Nacional de Saúde (FUNASA), Ministry of Health, Salvador, Brazil 5: Centro de Enfermidades Respiratórias & Serviço de Imunologia, Department of Medicine, Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil 6: Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 7: London School of Hygiene and Tropical Medicine, London, United Kingdom

Publication date: October 1, 2005

More about this publication?
  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • International Journal of Tuberculosis and Lung Disease
  • Public Health Action
  • ingentaconnect is not responsible for the content or availability of external websites
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more