Risk factors for drug-resistant tuberculosis among non-US-born persons in New York City
Authors: Clark, C. M.; Li, J.; Driver, C. R.; Munsiff, S. S.
Source: The International Journal of Tuberculosis and Lung Disease, Volume 9, Number 9, September 2005 , pp. 964-969(6)
Abstract:SETTING: New York City (NYC).
OBJECTIVES: To examine the extent to which prior tuberculosis (TB) treatment, length of residence in the United States and other factors are associated with the occurrence of drug resistance among non-US-born persons in NYC.
DESIGN: Cases were non-US-born persons diagnosed with TB in NYC from 1998–1999 and from 2001–2002, with an initial Mycobacterium tuberculosis isolate resistant to any first-line anti-tuberculosis drug. Controls were randomly selected from non-US-born persons whose isolates were susceptible to all first-line anti-tuberculosis drugs.
RESULTS: Overall, cases with multidrug-resistant (MDR) TB were more likely to have had prior TB treatment; other drug resistance was not associated with prior TB treatment. In a multivariate model, the relationship between MDR-TB and prior treatment remained significant for non-US-born persons regardless of length of time in the US.
CONCLUSIONS: The findings underscore the utility of monitoring trends in drug resistance among the non-US-born by time in the US and prior treatment to determine where or when drug resistance may be occurring.
Document Type: Regular Paper
Affiliations: Bureau of Tuberculosis Control, New York City Department of Health and Mental Hygiene, New York, New York, USA
Publication date: September 1, 2005
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