Clinical and epidemiological aspects of smoking and tuberculosis: a study of 13038 cases
DESIGN: A cross-sectional observational study of cases (TB with smoking) and controls (TB without smoking) from the same registry. Data were retrieved from case notes and interviews of patients registered in the Tuberculosis Control Programme in Cataluña, Spain, between 1 January 1996 and 31 December 2002. Statistical analyses included univariate and stepwise multiple logistic regression analyses.
RESULTS: There were 13038 recorded patients. Social factors associated with TB in smokers were male sex (adjusted odds ratio [aOR] 2.2), age <64 years, alcohol use >30 g/day (aOR 7.4) and intravenous drug use (aOR 1.5). Smokers developed more pulmonary disease (aOR 1.5) and more cavitary lesions (aOR 1.9), and were more likely to require hospitalisation (aOR 1.8) which was more protracted. Differences in mortality and delay in diagnosis did not reach statistical significance.
CONCLUSIONS: Smoking leads to faster and more severe progression of TB. The cost of TB-related hospitalisation for smokers increases by approximately one million euros per year.
Document Type: Regular Paper
Affiliations: 1: Unidad de Prevención y Control de la Tuberculosis (Barcelona), Barcelona, Spain 2: Dirección General de Salud Pública, Barcelona y Lleida, Cataluña, Spain 3: Universidad Internacional de Cataluña, Cataluña, Spain
Publication date: 2005-04-01
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