Role of mycobacteria-induced monocyte/macrophage apoptosis in the pathogenesis of human tuberculosis [Review Article]
The worldwide increase in tuberculosis has stimulated more research aimed at defining the interaction between Mycobacterium tuberculosis and the immune system. M. tuberculosis possesses sophisticated strategies to circumvent its fate within target monocytic cells. Apoptosis of alveolar macrophages and monocytes has been described as a consequence of M. tuberculosis infection. Moreover, the observation that mycobacterial lipoproteins activate macrophages through Toll-like receptor (TLR) 2 suggests that innate immune receptors contribute to defence against M. tuberculosis. There is evidence that TLR-induced apoptosis modulates inflammation and immune activation during M. tuberculosis infection. Finally, the role of apoptotic-infected cells as a source of microbial antigens for cross-priming of effector T-cells is also discussed.
Document Type: Review Article
Affiliations: 1: Division of Respiratory Medicine, ‘FEDERICO II’ University, Naples, Italy 2: Department of Clinical and Experimental Medicine, II University, Naples, Italy 3: Department of Biology, University of ‘Tor Vergata’, Rome, Italy 4: Research Centre, S Pietro-Fatebenefratelli Hospital, Rome, Italy
Publication date: 2005-04-01
The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.
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