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Free Content Drug susceptibility of Mycobacterium tuberculosis in HIV-infected and -uninfected Ethiopians and its impact on outcome after 24 months of follow-up

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Abstract:

From a prospective cohort study on tuberculosis/human immunodeficiency virus (TB/HIV) interaction in Addis Ababa, Ethiopia, drug susceptibility results were available for 94 TB patients (46% HIV-infected). Resistance to one or more drug(s) was detected in 21 (22.3%) and multidrug resistance in five (5.3%) patients. Occurrence of resistance was not related to HIV status or outcome after 24 months of follow-up. However, among HIV-infected TB patients who died during follow-up, survival time in those with a resistant Mycobacterium tuberculosis strain was significantly shorter compared to those with a sensitive strain (6 vs. 13 months). Early detection of drug resistance and timely treatment change can therefore have a positive impact on survival in HIV-infected TB patients.

Keywords: Ethiopia; HIV-1; drug resistance; long-term follow-up; tuberculosis

Document Type: Short Communication

Affiliations: 1: Ethiopian Health and Nutrition Research Institute (EHNRI), Addis Ababa, Ethiopia 2: Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia 3: Ethio-Netherlands AIDS Research Project, EHNRI, Addis Ababa, Ethiopia 4: Institute of Tropical Medicine, Antwerp, Belgium 5: National Institute of Public Health and the Environment, Bilthoven, The Netherlands 6: Institut Pasteur, Paris, France

Publication date: 2004-11-01

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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